ANTICORPI ANTIFOSFOLIPIDI

A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody sindrome.
New Eng J Med 2003, Sept 18, 1133

Studio randomizzato in doppio cieco su 114 pz ha rilevato che range moderato tra 2 – 3  è appropriato dopo i primi tre mesi.

 

Cerebrovasc Dis. 2005 Apr 29;19(6):384-390
Clinical Characteristics of Stroke Patients with Antiphospholipid Antibodies.

 Terashi H, Uchiyama S, Hashimoto S, Miyazaki K, Tsutsumi Y, Yamazaki M, Iwata M.

 Background: Antiphospholipid syndrome is important as a cause of ischemic stroke, although clinical characteristics of the syndrome are not well documented.

Methods: We analyzed differences in clinical characteristics between 40 antiphospholipid-antibody (aPL)-positive and 40 aPL-negative stroke patients.

Results: Stroke patients with aPL were significantly younger and were more likely  to be women in comparison with stroke patients without aPL.

Valvular heart disease, neurological complications and hematological disorders were more frequent in the aPL-positive group. The mean value of thrombin-antithrombin III complex was significantly lower in the aPL-positive group.

Cerebral infarctions in the carotid system were less and large-artery lesions more frequent in the

aPL-positive patients. Conclusions: Stroke patients with aPL have clinical characteristics distinct from stroke patients without aPL.

Rev Cardiovasc Med. 2006 Fall;7(4):244-6.Click here to read 

Antiphospholipid antibody syndrome and acute stent thrombosis.

Division of Cardiovascular Medicine, Department of Medicine, Lenox Hill Hospital, New York, NY.

Antiphospholipid antibody syndrome is an autoimmune disease characterized by the presence of antiphospholipid antibodies and at least 1 clinical manifestation, most commonly vascular thrombosis or fetal loss. Antiphospholipid antibodies are associated with multiple cardiac manifestations, including valve problems, thrombosis within cardiac chambers, and coronary artery thrombosis. We describe the case of a 46-year-old woman with recurrent coronary stent thrombosis who was found to have antiphospholipid antibodies. After successful coronary artery bypass graft surgery, the patient was kept on twice-daily injections of the low-molecular-weight heparin enoxaparin and started on warfarin. Six days after surgery, she was discharged from the hospital in stable condition.

Marzo 2007